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0 · Team Céline Prunier
1 · Mechanisms of action of NME metastasis suppressors
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Team leader (s) : Céline Prunier. Administrative contact : Sandrine Gromat. Saint-Antoine Hospital - Kourilsky Building – 4th floor. 184, rue du Faubourg Saint-Antoine - 75012 Paris - .
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NME1, the prototypic and first described metastasis suppressor gene, encodes a nucleoside diphosphate kinase (NDPK) involved in nucleotide metabolism; two related family members, .Team leader (s) : Céline Prunier. Administrative contact : Sandrine Gromat. Saint-Antoine Hospital - Kourilsky Building – 4th floor. 184, rue du Faubourg Saint-Antoine - 75012 Paris - France. Team members.
NME1, the prototypic and first described metastasis suppressor gene, encodes a nucleoside diphosphate kinase (NDPK) involved in nucleotide metabolism; two related family members, NME2 and NME4, are also reported as metastasis suppressors.
Team Céline Prunier
Mechanisms of action of NME metastasis suppressors
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New research out of VCU Massey Cancer Center points to the inactivation of a previously unidentified gene as a likely culprit in the development of pancreatic cancer.Doctorants, Master. Notre laboratoire s’intéresse aux aspects fondamentaux de la biologie des cellules cancéreuses et de la signalisation cellulaire induite par le TGF-β. Les altérations qui inactivent la signalisation du TGF-β sont connues pour déclencher des événements précoces de la tumorigenèse en supprimant les effets anti . PHRF1 functions as an essential component of the TGF-β tumor suppressor pathway by triggering degradation of the homeodomain repressor factor TGIF. This leads to redistribution of cPML into the cytoplasm, where it coordinates phosphorylation and activation of Smad2 by the TGF-β receptor.
Metastasis suppressor genes and their role in the tumor microenvironment. Cristina Megino-Luque. Jose Javier Bravo-Cordero. REVIEW 20 November 2023 Pages: 1147 - 1154.Céline Prunier 1 , Barbara A Hocevar, Philip H Howe. Affiliation. 1 Department of Cell Biology, NC1, Cleveland Clinic Lerner College of Medicine, Cleveland Clinic Foundation, Cleveland, OH 44195, USA. PMID: 15518237. DOI: 10.1080/08977190410001720860. Abstract.Abstract. Transforming growth factor β (TGF-β) is a potent natural antiproliferative agent that plays an important role in suppressing tumorigenicity. In numerous tumors, loss of TGF-β responsiveness is associated with inactivating mutations that can occur in components of this signaling pathway, such as the tumor suppressor Smad2.
Céline Prunier. Researcher. Institut National de la Santé et de la Recherche Médicale (INSERM) Paris, France.Here, we identify the protein cysteine and tyrosine-rich protein 1 (CYYR1) that had previously no assigned function, as a regulator of WWP1 activity and sta-bility. We show that CYYR1 binds to the WW domains of the E3 ubiquitin ligase WWP1 through its PPxY motifs.
Team leader (s) : Céline Prunier. Administrative contact : Sandrine Gromat. Saint-Antoine Hospital - Kourilsky Building – 4th floor. 184, rue du Faubourg Saint-Antoine - 75012 Paris - France. Team members.
NME1, the prototypic and first described metastasis suppressor gene, encodes a nucleoside diphosphate kinase (NDPK) involved in nucleotide metabolism; two related family members, NME2 and NME4, are also reported as metastasis suppressors. New research out of VCU Massey Cancer Center points to the inactivation of a previously unidentified gene as a likely culprit in the development of pancreatic cancer.Doctorants, Master. Notre laboratoire s’intéresse aux aspects fondamentaux de la biologie des cellules cancéreuses et de la signalisation cellulaire induite par le TGF-β. Les altérations qui inactivent la signalisation du TGF-β sont connues pour déclencher des événements précoces de la tumorigenèse en supprimant les effets anti .
PHRF1 functions as an essential component of the TGF-β tumor suppressor pathway by triggering degradation of the homeodomain repressor factor TGIF. This leads to redistribution of cPML into the cytoplasm, where it coordinates phosphorylation and activation of Smad2 by the TGF-β receptor.Metastasis suppressor genes and their role in the tumor microenvironment. Cristina Megino-Luque. Jose Javier Bravo-Cordero. REVIEW 20 November 2023 Pages: 1147 - 1154.Céline Prunier 1 , Barbara A Hocevar, Philip H Howe. Affiliation. 1 Department of Cell Biology, NC1, Cleveland Clinic Lerner College of Medicine, Cleveland Clinic Foundation, Cleveland, OH 44195, USA. PMID: 15518237. DOI: 10.1080/08977190410001720860. Abstract.Abstract. Transforming growth factor β (TGF-β) is a potent natural antiproliferative agent that plays an important role in suppressing tumorigenicity. In numerous tumors, loss of TGF-β responsiveness is associated with inactivating mutations that can occur in components of this signaling pathway, such as the tumor suppressor Smad2.
Céline Prunier. Researcher. Institut National de la Santé et de la Recherche Médicale (INSERM) Paris, France.
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